Antifungal efficacy of different extracts of neem and turmeric on candida species – An in vitro analysis

Indian Journal of Dental Sciences

article

Nallan C. S K. Chaitanya¹  Diksha Chikte¹  Kandari Ramya¹  Sushmitha Yadav¹  C Pravallika²  Sasi Vardhini²  Bhargavi Priya²  Baradi Keerthana²  Amal Fathima² 

[1] Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre;Department of Oral Medicine and Radiology, Panineeya Institute of Dental Sciences

关键词: Agar plates;    Candida;    curcumin;    disc diffusion;    neem;   

DOI  :  10.4103/ijds.ijds_52_21

学科分类：生物科学（综合）

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Background : Curcumin is an age-old spice, which is known for its anti-inflammatory activity and antibacterial property, and neem is proven to have many medicinal properties, especially known for its antimicrobial properties. Aim: The study aimed at assessing the antifungal activity of different preparations of turmeric and neem over Candida species. Materials and Methods: Using Sabouraud's agar as the medium, Candida species colonies were transferred to the agar plates after preparation of five wells. 75 μl, 50 μl, 25 μl, 10 μl, and 5 μl of neem leaf oil, neem oil, turmeric oil, turmeric extract, and neem seed oil were added and incubated at 37°C for 18–24 h. The diameter of inhibition zone around the wells where the growth was inhibited corresponded to the antifungal activity. Results: Neem bark extract and turmeric extract showed the highest inhibitory range against Candida albicans . Neem leaf extract showed the highest range of inhibition at 75% against Candida krusei and Candida tropicalis . Conclusion: Extracts of turmeric and neem have shown definitive inhibition against different strains of candida in vitro , and hence, these can be used for treating candidiasis as an alternative to regular triazoles.

【 授权许可】

CC BY-NC-SA