Saliva as a reliable diagnostic tool during the coronavirus disease times: A focused review

Indian Journal of Dental Sciences

article

Sarita Shaukari¹  Souren Bellam²  K Raghu Nandan³  Revathi Peddu¹ 

[1] Department of Orthodontics, SIBAR Institute of Dental Sciences;NRI Academy of Medical Sciences;Department of Oral and Maxillofacial Surgeon

关键词: Corona virus;    reverse transcription-polymerase chain reaction;    saliva and coronavirus disease-2019;    salivary diagnostics;    severe acute respiratory syndrome coronavirus 2;   

DOI  :  10.4103/IJDS.IJDS_206_20

学科分类：生物科学（综合）

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also currently known as CoV disease 2019 (COVID-19), has created a global health upheaval. The saliva of an infected person serves as a source for the transmission of CoV. The angiotensin-converting enzyme-2 receptors serve as the host receptor cells for CoV which is expressed in high numbers in salivary glands, oral mucosa, and gingiva. The salivary gland is a potential reservoir for COVID-19 even in asymptomatic but infected carriers. This knowledge could be used to employ salivary sampling as a noninvasive diagnostic method. IgA, IgM antibodies detected in self-collected saliva show more stability than RNA and may aid in the identification of asymptomatic patients. Saliva shows high sensitivity and specificity in the diagnosis of COVID-19 with >90% concordance reported between the saliva and nasopharyngeal swabs. Standardization with respect to sample collection, storage, and transport media can help in validation of diagnostic application of salivary-based testing.

【 授权许可】

CC BY-NC-SA