Metastatic small-cell carcinoma of the bladder that maintains a complete response to chemoradiation therapy

IJU Case Reports

article

Shinya Miyazaki¹  Takashi Ueda²  Ryosuke Tamai¹  Akihisa Ueno¹  Terukazu Nakamura¹ 

[1] Department of Urology, Saiseikai Suita Hospital;Department of Urology, Kyoto Prefectural University of Medicine

关键词: carboplatin;    irinotecan;    radiation;    small cell carcinoma;    urinary bladder;   

DOI  :  10.1002/iju5.12547

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

IntroductionSmall-cell carcinoma of the urinary bladder has a poor prognosis, and no standard treatment has been established. We encountered a case of a patient with metastasis in which complete response and long-term survival were obtained by treating the primary lesion with a combination of irinotecan, carboplatin chemotherapy, and radiation therapy. Case presentationAn 83-year-old man was diagnosed with a bladder tumor with liver metastasis. Small-cell carcinoma was diagnosed via transurethral resection. Second-line chemotherapy with irinotecan and carboplatin and irradiation of the primary lesion were significantly effective. The imaging evaluation showed a complete response. The therapeutic effect was maintained for 1 year, even after the discontinuation of chemotherapy. ConclusionIrinotecan and carboplatin should be considered for the treatment of small-cell carcinoma of the bladder. Irradiation of the primary lesion may also be useful if the extent of metastasis is low.

【 授权许可】

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