Risk stratification of sudden cardiac death in asymptomatic female Brugada syndrome patients: A literature review

Annals of noninvasive electrocardiology: the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

article

Keith Sai Kit Leung BSc¹  Danny Radford BSc³  Helen Huang⁴  Ishan Lakhani MSc¹  Christien Ka Hou Li MBBS⁵  Sandeep Singh Hothi⁶  Abraham Ka Chung Wai MBChB⁷  Tong Liu⁸  Gary Tse¹  Sharen Lee MBChB¹ 

[1] Cardiac Electrophysiology Unit, Cardiovascular Analytics Group;Faculty of Health and Life Sciences, Aston University Medical School;Kent and Medway Medical School, University of Kent and Canterbury Christ Church University;University of Medicine and Health Science, Royal College of Surgeons in Ireland;John Radcliffe Hospital, Oxford University Hospitals NHS Trust;Heart and Lung Centre, New Cross Hospital, Royal Wolverhampton NHS Trust;Emergency Medicine Unit, University of Hong Kong;Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University

关键词: Brugada syndrome;    gender difference;    risk stratification;    sudden cardiac death;   

DOI  :  10.1111/anec.13030

来源: Wiley

【 摘 要 】

Background and ObjectivesRisk stratification in Brugada syndrome remains a difficult problem. Given the male predominance of this disease and their elevated risks of arrhythmic events, affected females have received less attention. It is widely known that symptomatic patients are at increased risk of sudden cardiac death (SCD) than asymptomatic patients, while this might be true in the male population; recent studies have shown that this association might not be significant in females. Over the past few decades, numerous markers involving clinical symptoms, electrocardiographic (ECG) indices, and genetic tests have been explored, with several risk-scoring models developed so far. The objective of this study is to review the current evidence of clinical and ECG markers as well as risk scores on asymptomatic females with Brugada syndrome. FindingsGender differences in ECG markers, the yield of genetic findings, and the applicability of risk scores are highlighted. ConclusionsVarious clinical, electrocardiographic, and genetic risk factors are available for assessing SCD risk amongst asymptomatic female BrS patients. However, due to the significant gender discrepancy in BrS, the SCD risk amongst females is often underestimated, and there is a lack of research on female-specific risk factors and multiparametric risk scores. Therefore, multinational studies pooling female BrS patients are needed for the development of a gender-specific risk stratification approach amongst asymptomatic BrS patients.

【 授权许可】

Unknown