Safety of re-challenging adults with acute lymphoblastic leukemia with PEG-asparaginase-induced severe hypertriglyceridemia when treated with a pediatric-inspired regimen

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article

Ibrahim Al Nabhani¹  Claire Andrews¹  Jad Sibai¹  Eshetu Atenafu¹  Taylor Young¹  Steven M. Chan¹  Vikas Gupta¹  Dawn Maze¹  Aaron D. Schimmer¹  Andre C. Schuh¹  Karen Yee¹  Hassan Sibai¹ 

[1] Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network

关键词: acute lymphoblastic leukemia;    acute pancreatitis;    hypertriglyceridemia;    PEG-asparaginase;    toxicity;   

DOI  :  10.1002/jha2.607

来源: Wiley

【 摘 要 】

1000 mg/dl or 11.4 mmol/L). The incidence of hypertriglyceridemia associated with PEG-asparaginase in adult patients was high (67.5%). Therefore, checking TGs at baseline and monitoring levels while receiving PEG-asparaginase need to be considered and studied in prospective studies. However, in patients with hypertriglyceridemia not complicated by acute pancreatitis, re-challenging is safe once TG levels normalize.

【 授权许可】

Unknown