Predictors and clinical complications associated with antiphospholipid antibodies in sickle cell disease

eJHaem

article

Claudia Rodriguez Rivera¹  Andrew Srisuwananukorn²  Rizma Jalees Bajwa¹  Victor R. Gordeuk³  Joyce Rauch⁴  Jerrold S. Levine¹  Santosh L. Saraf³ 

[1] Department of Medicine, Division of Nephrology, University of Illinois at Chicago;Department of Medicine, Division of Hematology and Oncology, Mt Sinai Health System;Department of Medicine, Division of Hematology and Oncology, University of Illinois at Chicago;Department of Medicine, Division of Rheumatology, Research Institute of the McGill University Health Centre, McGill University;Department of Medicine, Division of Nephrology, Jesse Brown, Veterans Affairs Medical Center

关键词: antiphospholipid antibody;    antiphospholipid syndrome;    multiorgan failure;    sickle cell disease;    systemic lupus erythematosus;   

DOI  :  10.1002/jha2.643

来源: Wiley

【 摘 要 】

Although a higher prevalence of antiphospholipid autoantibodies (aPL) has been observed in some cohorts of sickle cell disease (SCD) patients, the clinical risk factors for the development of aPL and its associated complications remain unclear. In a retrospective study of 63 SCD patients, a lower hemoglobin concentration and higher white blood cell count were independently associated with an elevated aPL. SCD patients with elevated aPL had increased pregnancy complications (≥3 miscarriages, preterm delivery, pre-eclampsia) and venous thrombotic events. Our findings suggest that SCD may predispose to the generation of aPL and that aPL itself may contribute to the vasculopathy of SCD. Prospective testing for aPL is warranted in patients with SCD.

【 授权许可】

Unknown