One-step synthesis of silver nanostructures using Heracleum persicum fruit extract, their cytotoxic activity, anti-cancer and anti-oxidant activities

Micro & nano letters

article

Ali Dehnoee¹  Roozbeh Javad Kalbasi¹  Mohammad Mahdi Zangeneh²  Mohammad-Reza Delnavazi³  Akram Zangeneh² 

[1] Faculty of Chemistry, Kharazmi University;Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences;Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences

关键词: breast adenocarcinoma;    cell viability;    green nanoparticles;    plant extract;    silver nanostructures;   

DOI  :  10.1049/mna2.12153

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Bio-inspired techniques are used for synthesis in terms of application, green chemical research, facile, and eco-friendly chemistry study of silver nanostructures utilizing plant extracts as natural reducing/stabilization and solid adjuvants without the use of toxic and damaging reagents. The present study investigates the biosynthesis of Ag nanoparticles via the mediation of the methanolic extract of Heracleum persicum seeds, without utilizing any stabilizer or surfactant. These nanostructures were identified utilizing ultraviolet–visible spectroscopy, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, high-resolution transmission electron microscopy, Fourier-transform infrared spectroscopy and dynamic light scattering. The attributes of AgNPs versus usual human breast adenocarcinoma cell lines that is, Hs 281.T, MDA-MB-468, AU565 [AU-565], MCF7, CAMA-1, SK-BR-3, NMU, and RBA were evaluated. The livability of breast adenocarcinoma cell line diminishes dose-dependently in the existence of AgNPs. After clinical studies, AgNPs can be used as a green drug in the treatment of human breast adenocarcinoma.

【 授权许可】

CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND