What Causes Seizures in Neurocysticercosis?

Epilepsy currents

article

Teresa Julieta Simões Steyn¹  Amalia Naita Awala¹  Anja de Lange¹  Joseph Valentino Raimondo¹ 

[1] Division of Cell Biology, Department of Human Biology, Neuroscience Institute and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town

关键词: cestode;    inflammation;    neurocysticercosis;    seizures;    Taenia solium;   

DOI  :  10.1177/15357597221137418

学科分类：精神健康和精神病学

来源: Wiley

【 摘 要 】

Neurocysticercosis (NCC) is the most prevalent parasitic infection of the central nervous system. It is caused by the presence of larvae of the cestode Taenia solium in the brain. The most common symptom of NCC is seizures, and it is widely considered the world’s leading cause of preventable epilepsy. Despite the prevalence and impact of NCC, a thorough, mechanistic understanding of seizure generation is still lacking. In this review, we address the question “What causes seizures in NCC?” by summarizing and discussing the major theories that seek to explain the seizurogenic and epileptogenic processes in this disorder. In addition, we highlight the potential for recent advances in disease modeling to help accelerate progress in this area.

【 授权许可】

CC BY