Dravet Syndrome as an Example of Precision Medicine in Epilepsy

Epilepsy currents

article

Joseph Sullivan¹  Elaine C. Wirrell² 

[1] Department of Neurology and Pediatrics, Benioff Children’s Hospital Pediatric Epilepsy Center of Excellence, University of California San Francisco;Divisions of Child and Adolescent Neurology and Epilepsy, Department of Neurology, Mayo Clinic

关键词: Dravet;    precision medicine;    developmental epileptic encephalopathy;    anti seizure medication;    disease modifying therapy;    epilepsy syndrome;   

DOI  :  10.1177/15357597221106281

学科分类：精神健康和精神病学

来源: Wiley

【 摘 要 】

Dravet syndrome (DS) is a drug-resistant, early-onset, developmental and epileptic encephalopathy where there have been many recently approved therapies with many more in development. With the availability of more syndrome specific treatment options coupled with an earlier diagnosis, DS is well-positioned to be an example of how a precise syndromic diagnosis can guide treatment choices and improve overall outcomes and also allow for the development of potential disease modifying therapies to address more than just seizures. In this review we summarize the current state of DS approved therapies and those that are in various stages of development.

【 授权许可】

CC BY