Bioengineering Technology with a Social Responsibility

Berkeley Scientific: the journal of young scientists

article

Matthew Colbert ; Cassidy Hardin ; Michelle Lee ; Rosa Lee ; Melanie Russo ; Nikhil Chari

关键词: Luke Lee;    BIGHEART;    PCR-on-a-Chip Technology;    Microfluidics;    Plasmonic Bacteria;    Waterborne Pathogens;   

DOI  :  10.5070/BS3232045358

学科分类：社会科学、人文和艺术（综合）

来源: University of California, Berkeley

【 摘 要 】

LL: I originally started my career here in Berkeley, but backthen, I didn’t have much funding, physical space, or manpower to set up this institution. I wanted to create an environmentwhere people from different disciplines could work together to solveone problem—global health. Of course, there are so many differentissues within global health that need attention, but I wanted to focuson early infectious disease diagnostics and precision medicine usingorganoid chips—tissue cultures that can replicate the behavior andcomplexity of a real organ. Everyone’s metabolic activity is different,but even if we assume there is a universal recipe for treating a patient for a certain disease, certain people may still not be able to handle that treatment. In the case of cancer in Third World countries,if the patients are malnourished, they might not be able to handlethe same toxic compounds that are found in cancer medications. Wewere thinking about how to find the best personalized medicine fororganoid-on-a-chip technologies. But molecular diagnostics was ourfirst priority. That’s why I spent a lot of time developing more efficient technologies to detect DNA and protein biomarkers. That’s oneof the reasons we’re working on PCR-on-a-chip. If possible, we wantto detect the pathogen directly without any labeling.

【 授权许可】

Unknown