PI-07. Detection frequency of herpesviruses in colonic mucosal biopsies in the patients with intestinal complications after hematopoietic stem cell transplantation

Cellular Therapy and Transplantation

article

Alexander N. Shvetsov¹  Oleg V. Goloshchapov¹  Alexei B. Chukhlovin¹  Anna A. Spiridonova¹  Maria D. Vladovskaya¹  Ludmila S. Zubarovskaya¹  Alexander D. Kulagin¹ 

[1] RM Gorbacheva Research Institute, Pavlov University

关键词: Hematopoietic stem cell transplantation;    colonic mucosa;    biopsies;    herpesviruses;    detection rates;    clinical associations.;   

DOI  :  10.18620/ctt-1866-8836-2022-11-3-1-132

学科分类：肿瘤学

来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf

【 摘 要 】

Intestinal syndromes are common after allogeneic HSCT, due to acute graft-versus-host disease (aGVHD) and/or infectious conditions. Later on, they may manifest as overlap syndrome combining the features of acute and chronic GVHD. Early reactivation of herpesviruses is a common finding after intensive cytostatic therapy and HSCT. The aim of our study was to assess detection frequency of cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus type 6 (HHV6) and herpes simplex virus (HSV) in colonic mucosal biopsies within first 180 days post-HSCT, as well as their possible association with common clinical complications.

【 授权许可】

CC BY