CM-05. Determining predictors of unfavorable course in low- and intermediate-risk patients with myelodysplastic syndrome

Cellular Therapy and Transplantation

article

Ksenia S. Yurovskaya¹  Elena V. Morozova¹  Maria V. Barabanshchikova¹  Nikolay Y. Tsvetkov¹  Yulia Yu. Vlasova¹  Tatiana L. Gindina¹  Ildar M. Barkhatov¹  Ivan S. Moiseev¹  Alexander D. Kulagin¹ 

[1] RM Gorbacheva Research Institute, Pavlov University

关键词: Myelodysplastic syndrome;    clinical outcomes;    prognostic factors.;   

DOI  :  10.18620/ctt-1866-8836-2022-11-3-1-132

学科分类：肿瘤学

来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf

【 摘 要 】

Life expectancy of the patients with low- and intermediate-risk myelodysplastic syndrome (MDS) does not always correspond to the IPSS prognostic system (IPSS-R). According to the literature data, deterioration of clinical prognosis is associated with distinct factors, e.g., lack of response to therapy, infectious complications due to neutropenia, iron overload caused by blood transfusions, presence of the bone marrow fibrosis, development of secondary MDS after previous chemo- and radiotherapy. The predictors of potential transformation into refractory anemia 1-2 with blast excess and acute myeloid leukemia are insufficiently studied so far. Our study was aimed for determining the predictors of unfavorable course of myelodysplastic syndrome in the patients with low-to-intermediate risk of IPSS-R.

【 授权许可】

CC BY