Eficácia da lomustina no tratamento do tumor venéreo transmissível canino

Ciencia Rural

article

Thiago Souza Costa¹  Felipe Noleto de Paiva²  Bruna Sampaio Martins Land Manier¹  Cecília Lopes da Conceição¹  Andressa Aparecida de Lima Reis¹  Julio Israel Fernandes¹ 

[1] Universidade Federal Rural do Rio de Janeiro;Universidade Estadual Paulista

关键词: neoplasm;    chemotherapy;    alkylants;    lomustine;    venereal tumour;    dogs;   

DOI  :  10.1590/0103-8478cr20220120

学科分类：农业科学（综合）

来源: Universidade Federal de Santa Maria * Centro de Ciencias Rurais

【 摘 要 】

Canine transmissible venereal tumor (TVTC) is a highly casuistic transmissible neoplasm in Brazil. Chemotherapy with vincristine sulfate is considered the treatment of choice, but the need for weekly applications and hematological monitoring, in addition to costs, are obstacles to owners’ adhesion to the treatment. Lomustine is an alkylating class antineoplastic agent, and because it is administered orally, it is a more practical and less costly treatment option for the owners of animals with neoplasms sensitive to the drug. This study evaluated the therapeutic efficacy of lomustine in dogs affected by TVTC. Twelve dogs with cytopathological diagnosis of natural genital TVTC were selected. The dogs were submitted to the experimental protocol with lomustine administration at doses of 70 to 85 mg/m2 orally every 21 days, totaling a maximum of two administration cycles. The animals were reevaluated every 7 days until a maximum of +49 days after the first dose of lomustine, to monitor the regression of neoplastic lesions through measurements. Among the 12 dogs submitted to the lomustine protocol, 8/12 achieved complete remission of the neoplasm and were considered cured (66.6%), 1/12 had partial response to treatment (8.33%) and 3/12 had stable disease (25%). Important adverse effects such as severe neutrophilic leukopenia were detected in 3/12 dogs (25%). The clinical study indicated that lomustine may be a treatment option for TVTC.

【 授权许可】

Unknown