Babeisa duncani infection alters gut microbiota profile in hamsters

The Korean Journal of Parasitology

article

Shangdi Zhang¹  Jinming Wang²  Xiaoyun Li²  Yanbo Wang¹  Yueli Nian¹  Chongge You¹  Dekui Zhang¹  Guiquan Guan² 

[1] Lanzhou University Second Hospital;State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

关键词: Babesia duncani;    gut microbiota;    human babesiosis;    biomarker;    16S rRNA gene;   

DOI  :  10.3347/PHD.22142

学科分类：生物科学（综合）

来源: The Korean Society for Parasitology

【 摘 要 】

The genus Babesia includes parasites that can induce human and animal babesiosis, which are common in tropical and subtropical regions of the world. The gut microbiota has not been examined in hamsters infected by Babesia duncani. Red blood cells infected with B. duncani97.0% sequence similarity to create amplicon sequence variants (ASVs). Bacteroidetes and Firmicutes were made up of the major components of the gut microbiota in all samples. The abundance of Bacteroidetes elevated after B. duncani infection than the B. duncani-free group, while Firmicutes and Desulfobacterota declined. Alpha diversity analysis demonstrated that the shown ASVs were substantially decreased in the highest parasitemia group than B. duncani-free and lower parasitemia groups. Potential biomarkers were discovered by Linear discriminant analysis Effect Size (LEfSe) analysis, which demonstrated that several bacterial families (including Muribaculaceae, Desulfovibrionaceae, Oscillospiraceae, Helicobacteraceae, Clostridia UGG014, Desulfovibrionaceae, and Lachnospiraceae) were potential biomarkers in B. duncani-infected hamsters. This research demonstrated that B. duncani infectious can modify the gut microbiota of hamsters.

【 授权许可】

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