A comprehensive network map of IL-17A signaling pathway

Journal of Cell Communication and Signaling

article

Rex, D. A. B.¹  Dagamajalu, Shobha²  Gouda, Mahesh Manjunath³  Suchitha, G. P.²  Chanderasekaran, Jaikanth⁴  Raju, Rajesh¹  Prasad, T. S. Keshava²  Bhandary, Yashodhar Prabhakar⁵ 

[1] Centre for Integrative Omics Data Science, Yenepoya ,(Deemed to be University);Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya ,(Deemed to be University);Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg;Department of Pharmacology, School of Pharmacy and Technology Management, SVKM’S NMIMS University;Yenepoya Research Centre, Yenepoya ,(Deemed to be University)

关键词: Inflammation;    Bleomycin;    Protein–protein interactions;    Fibrosis;    Lung injury;    Signaling pathways;    Cytokines;   

DOI  :  10.1007/s12079-022-00686-y

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Interleukin-17A (IL-17A) is one of the member of IL-17 family consisting of other five members (IL-17B to IL-17F). The Gamma delta (γδ) T cells and T helper 17 (Th17) cells are the major producers of IL-17A. Aberrant signaling by IL-17A has been implicated in the pathogenesis of several autoimmune diseases including idiopathic pulmonary fibrosis, acute lung injury, chronic airway diseases, and cancer. Activation of the IL-17A/IL-17 receptor A (IL-17RA) system regulates phosphoinositide 3-kinase/AKT serine/threonine kinase/mammalian target of rapamycin (PI3K/AKT/mTOR), mitogen-activated protein kinases (MAPKs) and activation of nuclear factor-κB (NF-κB) mediated signaling pathways. The IL-17RA activation orchestrates multiple downstream signaling cascades resulting in the release of pro-inflammatory cytokines such as interleukins (IL)-1β, IL-6, and IL-8, chemokines (C-X-C motif) and promotes neutrophil-mediated immune response. Considering the biomedical importance of IL-17A, we developed a pathway resource of signaling events mediated by IL-17A/IL-17RA in this study. The curation of literature data pertaining to the IL-17A system was performed manually by the NetPath criteria. Using data mined from the published literature, we describe an integrated pathway reaction map of IL-17A/IL-17RA consisting of 114 proteins and 68 reactions. That includes detailed information on IL-17A/IL-17RA mediated signaling events of 9 activation/inhibition events, 17 catalysis events, 3 molecular association events, 68 gene regulation events, 109 protein expression events, and 6 protein translocation events. The IL-17A signaling pathway map data is made freely accessible through the WikiPathways Database (https://www.wikipathways.org/index.php/Pathway: WP5242).

【 授权许可】

CC BY