Chromatin is a Dynamic Structure

Resonance

article

Rajiva Raman¹ 

[1]Cytogenetics Laboratory, Department of Zoology

关键词: Chromatin;    nucleosome;    histones;    chromosomes;    DNA;    nuclear matrix;    scaffold;    TAD;    G-banding.;   

DOI  :  10.1007/s12045-022-1392-4

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

$100 kb long `topologically associating domains' (TADs) have been identified at the genome level as the functional unit of chromatin. For its differential functional states, chromatin constantly undergoes condensation and decondensation, mediated by the post-translational modification of histones (e.g. acetylation, methylation of lysine) and the displacement of nucleosomes by an ATP-dependent complex of proteins (e.g. SWI/SNF). DNA methylation is another mode of chromatin modification that affects chromatin function. Thus, a highly dynamic system of chromatin organisation not only encapsulates a large amount of DNA in the nucleus but ensures differential gene function in an orderly fashion.

【 授权许可】

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