Dosimetry in Radiopharmaceutical Therapy

The Journal of Nuclear Medicine

article

Joe O’Donoghue¹  Pat Zanzonico¹  John Humm¹  Adam Kesner¹ 

[1] Department of Medical Physics, Memorial Sloan Kettering Cancer Center

关键词: radionuclide therapy;    alpha particles;    Auger electrons;    dosimetry;    radiobiology;    radiopharmaceutical;   

DOI  :  10.2967/jnumed.121.262305

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The application of radiopharmaceutical therapy for the treatment of certain diseases is well established, and the field is expanding. New therapeutic radiopharmaceuticals have been developed in recent years, and more are in the research pipeline. Concurrently, there is growing interest in the use of internal dosimetry as a means of personalizing, and potentially optimizing, such therapy for patients. Internal dosimetry is multifaceted, and the current state of the art is discussed in this continuing education article. Topics include the context of dosimetry, internal dosimetry methods, the advantages and disadvantages of incorporating dosimetry calculations in radiopharmaceutical therapy, a description of the workflow for implementing patient-specific dosimetry, and future prospects in the field.

【 授权许可】

CC BY