A Guideline for Clinicians Performing Clinical Studies with Fluorescence Imaging

The Journal of Nuclear Medicine

article

Wido Heeman¹  Jasper Vonk²  Vasilis Ntziachristos³  Brian W. Pogue⁴  Rudi A.J.O. Dierckx⁵  Schelto Kruijff⁶  Gooitzen M. van Dam⁵ 

[1] University of Groningen, Faculty Campus Fryslân;Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen;Chair of Biological Imaging, Center for Translational Cancer Research ,(TranslaTUM), Technical University of Munich;Thayer School of Engineering and Department of Surgery, Dartmouth College;Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University Medical Center Groningen, University of Groningen;Department of Surgery, University Medical Center Groningen, University of Groningen;AxelaRx/TRACER B.V.

关键词: optical;    research methods;    clinical translation;    fluorescence imaging;    molecular imaging;    optical imaging;   

DOI  :  10.2967/jnumed.121.262975

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Fluorescence imaging is an emerging imaging technique that has shown many benefits for clinical care. Currently, the field is in rapid clinical translation, and an unprecedented number of clinical trials are performed. Clinicians are inundated with numerous opportunities and combinations of different imaging modalities. To streamline this process, a multidisciplinary approach is needed with drug discovery, software and systems engineering, and translational medicine. Here, we discuss the main constituents of a uniform fluorescence imaging protocol to match the clinical need and ensure consistent study designs and reliable data collection in clinical trials. In an era in which the potential of fluorescence imaging has become evident, consistent conduct of studies, data analysis, and data interpretation is essential for implementation into the standard of care.

【 授权许可】

CC BY