Combined Metabolically Active Tumor Volume and Early Metabolic Response Improve Outcome Prediction in Metastatic Colorectal Cancer

The Journal of Nuclear Medicine

article

Erwin Woff¹  Lisa Salvatore²  Federica Marmorino³  Dario Genovesi⁴  Gabriela Critchi¹  Thomas Guiot¹  Lieveke Ameye⁵  Francesco Sclafani⁶  Alain Hendlisz⁶  Patrick Flamen¹ 

[1] Nuclear Medicine Department, Institut Jules Bordet–Université Libre de Bruxelles;Medical Oncology Department, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS;Department of Translational Research and New Technologies in Medicine and Surgery, Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana;Nuclear Medicine Department;Data Centre, Institut Jules Bordet–Université Libre de Bruxelles;Medical Oncology Department, Institut Jules Bordet–Université Libre de Bruxelles

关键词: 18F-FDG PET/CT-based biomarkers;    metabolically active tumor volume;    early metabolic response;    metastatic colorectal cancer;   

DOI  :  10.2967/jnumed.120.245357

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Stratification of metastatic colorectal cancer (mCRC) patients is mostly based on clinical and biologic characteristics. This study aimed to validate the prognostic value of 18F-FDG PET/CT–based biomarkers such as baseline whole-body metabolically active tumor volume (WB-MATV) and early metabolic response (mR) in mCRC. Methods: The development cohort included chemorefractory mCRC patients enrolled in 2 prospective Belgian multicenter trials evaluating last-line treatments (multikinase inhibitors). The validation cohort included mCRC patients from an Italian center treated with chemotherapy and bevacizumab as first-line. Baseline WB-MATV was defined as the sum of metabolically active volumes of all target lesions identified on the baseline 18F-FDG PET/CT. Early mR assessment was performed following usual response criteria (response threshold of 30% [PERCIST–30%], response threshold of 15% [PERCIST–15%], European Organization for Research and Treatment of Cancer) and the so-called CONSIST method, which defines response as a decrease of SULmax ≥ 15% for all target lesions. Baseline WB-MATV and early mR assessment were investigated along with usual clinical factors and correlated with overall survival (OS) and progression-free survival (PFS). Results: Clinical factors, baseline WB-MATV, and early mR were evaluable in 192 of 239 and 94 of 125 patients of the development and validation cohorts, respectively. Except for PERCIST–30%, all response methods were equivalent in terms of outcome prediction, and CONSIST was found to be the most accurate. Baseline WB-MATV and early mR using the CONSIST method were independent prognostic parameters after adjustment for clinical factors in the development and validation sets for both OS (hazard ratio [HR] WB-MATV: 1.87 [95% CI, 1.17–2.97], P = 0.005, and HR early mR: 1.79 [95% CI, 1.08–2.95], P = 0.02 for the validation set) and PFS (HR WB-MATV: 1.94 [95% CI, 1.27–2.97], P = 0.002, and HR early mR: 1.69 [95% CI, 1.04–2.73], P = 0.03 for the validation set). Conclusion: Baseline WB-MATV and early mR are strong independent prognostic biomarkers for OS and PFS in mCRC, regardless of treatment received. Therefore, combining these biomarkers improves risk stratification for OS and PFS in mCRC.

【 授权许可】

CC BY