Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil

Sociedade Brasileira de Medicina Tropical. Revista

article

Finardi, Amanda Juliane¹  Oliveira, Nathan Guilherme de¹  Moraes, Eloise Brasil de¹  Batista, Lavínia Cássia Ferreira¹  Bortolomai, Bruna Eduarda¹  Suffys, Philip Noel²  Baptista, Ida Maria Foschiani Dias¹ 

[1]Instituto Lauro de Souza Lima

[2]Fundação Oswaldo Cruz

关键词: Leprosy;    Transmission;    Mycobacterium leprae;    Genetic Diversity;    Geographic Information System;   

DOI  :  10.1590/0037-8682-0612-2022

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Background:Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006. Methods: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state. Results: The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity. Conclusions:A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented.

【 授权许可】

CC BY