Introducing Protein Homeostasis and Glycogen Synthesis as Two Targets of Blue Light Radiation in Lentinula edodes

Journal of Lasers in Medical Sciences

article

RezaVafaee¹  MaryamHamzeloo-Moghadam³  ZahraRazzaghi²  MahfamNikzamir⁴  MohammadRostami Nejad⁵  Vahid Mansouri⁶ 

[1] Critical Care Quality Improvement Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences;Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences;Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences;Faculty of Medicine, Shahid Beheshti University of Medical Sciences;Research Institute for Gastroenterology and Liver Diseases, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences;Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences

关键词: Blue light;    Proteomics;    GlycoGlycogen;    Protein Degradation Co expression;   

DOI  :  10.34172/jlms.2022.47

学科分类：基础医学

来源: Shahid Beheshti University of Medical Sciences

【 摘 要 】

Introduction: There are documents about biological effects of blue light radiation on different organisms. Molecular mechanism understanding of radiation effects on biological samples is an important event which attracted attention of researchers. Determining of the critical dysregulated proteins of Lentinula edodes following blue light radiation is the aim of this study. Methods: Number of 22 differentially expressed proteins of Lentinula edodes in response to 300 lux of blue light were extracted from literature. Experimental, text mining, and co-expression connections between the queried proteins were assessed via STRING database. The maps were compared and the critical proteins were identified. Results: Among the 21 queried proteins, six individuals including; heat shock HSP70 protein, 20S proteasome subunit, 26S proteasome subunit P45, Aspartate aminotransferase, Phosphopyruvate hydratase, and Phosphoglucomutase were highlighted as the critical proteins in response to blue light radiation.   Conclusion: Finding indicates that protein homeostasis and glycogen synthesis are affected by blue light radiation.

【 授权许可】

CC BY