FEM Investigation of Silver Nanospheres, Nanoellipsoid, Nanorods and Core Shell Structures for Hyperthermia

Der Pharmacia Lettre

article

Muhammad Usama Daud¹ 

[1] Department of Physics, University of Riphah, Faisalabad

关键词: COMSOL multiphysics;    Hyperthermia;    Core-shell structure;    Finite element analysis;   

DOI  :  10.37532/dpl.2022.14.1

学科分类：药理学

来源: Scholars Research Library

【 摘 要 】

The finite element analysis approach was utilized to examine the appropriateness of silver nano-rods, spheres, ellipsoids, and core–shell structures for cancer hyperthermia therapy. To eliminate the malignant cells, the temperature of the silver nanostructures was increased from 42 to 46°C. The time it took the nanostructures to reach this temperature when heated by an external source was also calculated. For the finite element study of hyperthermia based on silver nanostructures, the heat transport module in COMSOL multiphysics was employed. The heat sensitivity of various forms of silver nanostructures was studied by inserting them inside the tumor tissue's spherical domain. At various time intervals, the suggested geometries were heated. In order to attain the optimal treatment temperature, the geometries were optimized. When compared to alternative forms, silver nano-rods reach the correct temperature rapidly. Among all the investigated geometries, the silver nano-rods reached the greatest temperature of 44.3°C. Furthermore, the silver nano-ellipsoids had the largest core volume, which was utilized to determine thermal responsiveness. After 0.5 μ s of heating, thermal equilibrium was achieved in the treatment zone, making these structures appropriate for hyperthermia therapy.

【 授权许可】

CC BY