Long-Term Survival Outcomes of Patients with Small (≤1 cm) Node-Negative HER2-Positive Breast Cancer Not Treated with Adjuvant Anti-HER2-Targeted Therapy: A 10-Year Follow-Up Study

Breast care

article

Liikanen, Jenni S.¹  Leidenius, Marjut¹  Joensuu, Heikki²  Meretoja, Tuomo J.¹ 

[1] Comprehensive Cancer Center, Breast Surgery Unit, Helsinki University Hospital and University of Helsinki;Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki

关键词: Breast cancer;    Survival;    Oestrogen receptor;    Human epidermal growth factor receptor 2;    HER2;   

DOI  :  10.1159/000520793

学科分类：泌尿医学

来源: S Karger AG

【 摘 要 】

Introduction: Human epidermal growth factor receptor 2 (HER2) expression is considered an unfavourable prognostic factor in early breast cancer when the patients are not treated with HER2-targeted therapy. However, the long-term prognostic importance of HER2 expression in small (≤1 cm, stage pT1a-b), node-negative HER2+ breast cancer is still incompletely known. Methods: A retrospective analysis was performed based on a prospectively collected database including patients with pT1 breast cancer operated at the Helsinki University Hospital, Finland, between March 2000 and April 2006. In this database, 44 patients with pT1a-bN0M0, HER2+ cancer, not treated with adjuvant anti-HER2-targeted therapy (the HER2+ group) and 291 pT1a-bN0M0, hormone receptor-positive, HER2-negative cancers (the ER+/HER2– group) were identified and included in the study. Survival outcomes were analysed using the Kaplan-Meier method. Results: The median follow-up time was 9.7 years after primary breast surgery. Ten-year distant disease-free survival (DDFS) was 84.0% in the HER2+ group and 98.2% in the ER+/HER2– group (p < 0.001). Ten-year overall survival was only 78.5% in the HER2+ group, but 91.7% in the ER+/HER2– group (p = 0.09). Conclusions: Cancer HER2 status is strongly associated with unfavourable DDFS during the first decade of follow-up in patients with small (pT1a-bN0M0) breast cancer when adjuvant anti-HER2-targeted treatment is not administered.

【 授权许可】

CC BY