Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer

Breast care

article

Witzel, Isabell¹  Zeder-Göß, Christine²  Schmutzler, Rita K.³  Rhiem, Kerstin³  Auber, Bernd⁴  Briest, Susanne⁵  Dikow, Nicola⁶  Ditsch, Nina²  Dragicevic, Neda⁷  Grill, Sabine⁸  Hahnen, Eric³  Horvath, Judit⁹  Jaeger, Bernadette^1,10  Kast, Karin³  Kiechle, Marion⁸  Leinert, Elena^1,11  Morlot, Susanne⁴  Püsken, Michael^1,12  Schäfer, Dieter^1,13  Schott, Sarah^1,14  Schroeder, Christopher^1,15  Siebers-Renelt, Ulrike⁹  Solbach, Christine^1,16  Weber-Lassalle, Nana³ 

[1]Department of Obstetrics and Gynaecology, University Medical Center Hamburg-Eppendorf

[2]Department of Gynecology and Obstetrics, University Hospital of Augsburg

[3]Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology, Cologne, Faculty of Medicine, University Hospital Cologne

[4]Department of Human Genetics, Hannover Medical School

[5]Department of Obstetrics and Gynaecology, University Hospital of Leipzig

[6]Institute of Human Genetics, University of Heidelberg

[7]Institute of Human Genetics, Julius-Maximilians-Universität Würzburg

[8]Department of Gynecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technical University Munich

[9]Institute for Human Genetics, University Hospital Münster

[10]Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf

[11]Department of Gynaecology and Obstetrics, University Hospital Ulm

[12]Department of Radiology, Faculty of Medicine, University Hospital Cologne

[13]Institute for Human Genetics, University of Frankfurt

[14]Department of Obstetrics and Gynaecology, University of Heidelberg

[15]Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen

[16]Department of Gynecology and Obstetrics, University Hospital Frankfurt

关键词: Consensus;    Panel testing;    Hereditary breast cancer;    Hereditary ovarian cancer;    BRCA1;    BRCA2;   

DOI  :  10.1159/000516376

学科分类：泌尿医学

来源: S Karger AG

【 摘 要 】

Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer. Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.

【 授权许可】

CC BY