Soluble CD14 and Osteoprotegerin Associate with Ankle-Brachial Index as a Measure of Arterial Stiffness in Patients with Mild-to-Moderate Chronic Kidney Disease in a Five-Year Prospective Study

Cardiorenal medicine

article

Eriksson, Maria J¹  Hylander, Britta²  Lundahl, Joachim³  Jacobson, Stefan H⁴  Sendic, Senka⁴  Mansouri, Ladan³  Hong, Mun-Gwan⁵  Schwenk, Jochen M⁵ 

[1] Department of Clinical Physiology, Karolinska University Hospital, Department of Molecular Medicine and Surgery, Karolinska Institutet;Division of Nephrology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital;Department of Clinical Science and Education, Karolinska Institutet;Division of Nephrology, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital;Affinity Proteomics, Science for Life Laboratory, KTH Royal Institute of Technology

关键词: Chronic kidney disease;    Arterial stiffness;    Ankle-brachial index;    Soluble cluster of differentiation 14;   

DOI  :  10.1159/000530985

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Introduction: Vascular lesions and arterial stiffness appear at early stages of chronic kidney disease (CKD) and follow an accelerated course with disease progression, contributing to high cardiovascular mortality. There are limited prospective data on mechanisms contributing to progression of arterial stiffness in mild-to-moderate CKD (stages 2–3). Methods: We applied an affinity proteomics approach to identify candidates of circulating biomarkers with potential impact on vascular lesions in CKD and selected soluble cluster of differentiation 14 (sCD14), angiogenin (ANG), and osteoprotegerin (OPG) for further analysis. We studied their association with ankle-brachial index (ABI) and carotid intima-media thickness, as measures of arteriosclerosis and atherosclerosis, respectively, in 48 patients with CKD stages 2–3, who were prospectively followed and intensively treated for 5 years, and 44 healthy controls. Results: Concentrations of sCD14 (p < 0.001), ANG (p < 0.001), and OPG (p < 0.05) were higher in patients with CKD 2–3 at baseline, and sCD14 (p < 0.001) and ANG (p < 0.001) remained elevated in CKD patients at follow-up. There were positive correlations between ABI and sCD14 levels (r = 0.36, p = 0.01) and between ABI and OPG (r = 0.31, p = 0.03) at 5 years. The changes in sCD14 during follow-up correlated to changes in ABI from baseline to 5 years (r = 0.41, p = 0.004). Conclusion: Elevated levels of circulating sCD14 and OPG in patients with CKD 2–3 were significantly associated with ABI, a measure of arterial stiffness. An increase in sCD14 over time in CKD 2–3 patients was associated with a corresponding increase in ABI. Further studies are needed to examine if early intensive multifactorial medication to align with international treatment targets may influence cardiovascular outcomes.

【 授权许可】

CC BY