Association of Cancer Antigen 125 with Long-Term Prognosis in Light-Chain Cardiorenal Amyloidosis

Cardiorenal medicine

article

Wu, Bifeng¹  Shi, Jiaran¹  Yu, Fangcong¹  Wu, Yakui¹  Tao, Xinran¹  Xuan, Tianming¹  Yang, Jinxiu¹  Wang, Xingxiang¹ 

[1] Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine

关键词: Light-chain cardiorenal amyloidosis;    Cancer antigen 125;    Left ventricular longitudinal strain;    Prognosis;   

DOI  :  10.1159/000527442

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Introduction: Light-chain (AL) cardiorenal amyloidosis has been characterized as type 5 cardiorenal syndrome with fluid overload and poor prognosis. Cancer antigen 125 (CA125) has the potential for its use in evaluating fluid load and prognosis for heart failure. However, less details for CA125 in AL cardiorenal amyloidosis have been reported. Methods: Sixty patients diagnosed with AL cardiorenal amyloidosis were enrolled in this retrospective study. Patients were divided into two groups according to the cutoff point of CA125 level (35 U/mL). Logistic regression was used to screen variables associated with CA125. Cox regression analyses were utilized to verify the prognostic potential of CA125. Results:II, pericardial effusion, and edema, as well as a lower level of albumin and left ventricular longitudinal strain (LVLS). Logistic regression showed age, albumin, and LVLS to be independently associated with CA125. Seventeen (28%) patients died during the follow-up. Multivariate model including CA125, estimated glomerular filtration rate, E/e’, and left ventricular ejection fraction showed acceptable prognostic potential (C-index = 0.829, 95% CI: 0.749–0.909). CA125 remained an independent prognostic factor (HR = 1.018, 95% CI: 1.005–1.031, p = 0.008, per 10 U/mL increase) after adjusting for the remaining three variates and provided a significant incremental effect to the risk determined from them (C-index 0.829 vs. 0.784, p = 0.037). Conclusion: Serum CA125 level was associated with long-term prognosis of AL cardiorenal amyloidosis.

【 授权许可】

CC BY