Time Is Kidney: Relation between Pain-to-Balloon Time and Acute Kidney Injury among ST Segment Elevation Patients Undergoing Primary Percutaneous Intervention

Cardiorenal medicine

article

Banai, Shmuel¹  Shacham, Yacov¹  Zahler, David¹  Lee-Rozenfeld, Keren¹  Itach, Tamar¹  Lupu, Lior¹ 

[1] Department of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University

关键词: Time to reperfusion;    Ischemia;    Acute kidney injury;    Acute myocardial infarction;   

DOI  :  10.1159/000523829

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Background: Among ST segment elevation myocardial infarction (STEMI), early hemodynamic changes may result in acute kidney injury (AKI) even prior to primary percutaneous coronary intervention (PCI); however, no information to date is present regarding the association between pain-to-balloon time (PBT) and AKI. We evaluated whether PBT predicts the risk of AKI among STEMI patients undergoing primary PCI. Methods:360 min. Patients’ records were assessed for the occurrence of AKI (defined by the KDIGO criteria as serum creatinine (sCr) elevation ≥0.3 mg/dL within 72 h after admission). Results: Mean age was 61 ± 13 years, and 1,919 (82%) were male. Patients having longer PBT had more AKI complicating the course of STEMI (7% vs. 8% vs. 13%, p < 0.001) and had significantly higher sCr changes throughout hospitalization (0.08 mg/dL vs. 0.11 mg/dL vs. 0.17 mg/dL p < 0.001). In a multivariable logistic regression model, each 1-h increase in PBT was independently associated with a 2.2% increase in risk for AKI (odds ratio 1.022, 95% confidence interval: 1.01–1.04, p = 0.02). Conclusion: Longer PBT may be an independent marker for the development of AKI in STEMI patients undergoing primary.

【 授权许可】

CC BY