Antibiotic consumption and time to recovery from uncomplicated urinary tract infection: secondary analysis of observational data from a point-of-care test trial

The British journal of general practice: the journal of the Royal College of General Practitioners

article

Amal Gadalla¹  Hannah Wise¹  Daniel Farewell¹  Kathryn Hughes²  Carl Llor³  Michael Moore⁴  Theo JM Verheij⁵  Paul Little⁴  Christopher C Butler⁶  Nick A Francis⁷ 

[1] Division of Population Medicine;PRIME Centre Wales, Division of Population Medicine, Cardiff University;Department of Public Health, University of Southern Denmark, Denmark, University Institute in Primary Care Research Jordi Gol, Via Roma Health Centre;School of Primary Care, Population Sciences and Medical Education, University of Southampton;Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht;Nuffield Department of Primary Care Health Sciences, University of Oxford;Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK, School of Primary Care, Population Sciences and Medical Education, University of Southampton

关键词: anti-bacterial agents;    antibiotic consumption;    general practice;    recovery without antibiotics;    uncomplicated;    urinary tract infections;   

DOI  :  10.3399/BJGP.2022.0011

学科分类：卫生学

来源: Royal College of General Practitioners

【 摘 要 】

Background Randomised trials provide high-quality evidence on the effects of prescribing antibiotics for urinary tract infection (UTI) but may not reflect the effects in those who consume antibiotics. Moreover, they mostly compare different antibiotic types or regimens but rarely include a ‘no antibiotic’ group.Aim To estimate the effect of antibiotic consumption, rather than prescription, on time to recovery in females with uncomplicated UTI.Design and setting Secondary analysis of 14-day observational data from a point-of-care test trial for UTI in primary care in England, the Netherlands, Spain, and Wales, which ran from 2012 to 2014. Clinicians treated patients using their own judgement, providing immediate, delayed, or no antibiotic.Method3 standardised antibiotic days. To account for confounders, a robust propensity score matching analysis was conducted. Adjusted Kaplan–Meier and Cox proportional hazard models were employed to estimate time to recovery and hazard ratios, respectively.Results A total of n = 333 females who consumed antibiotics and n3 standardised antibiotic days (7 days, 95% CI = 6 to 9).Conclusion Consuming antibiotics was associated with a reduction in self-reported time to recovery, but more antibiotics exposure was not associated with faster recovery in this study.

【 授权许可】

Free