Red Cell Alloimmunization In Rh D Positive Women: A Rare Case Report.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Deepika Aggarwal¹  Neetu Kukar²  RN Maharishi³  Anjali Handa.² 

[1] PGIMER;Guru Gobind Singh Medical College and Hospital;Adesh Institute of Medical Sciences and Research

关键词: Red cell alloimmunization;    Rh D positive women;   

DOI  :  10.33887/rjpbcs/2023.14.1.23

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Rh D antigen is the most important cause of alloimmunization in pregnant females. Anti-K, anti-c,a anti-Fy and Anti-E are the most serious causes of HDFN after anti-D . The present case emphasizes theneed of screening of other minor antibodies like Anti-C antibody in pregnant woman who gives asuggestive history but no evidence of anti-D. Herewith we reported a case of , 26 year old female wasadmitted with complaint of weakness and fever for 4 days inMedicine department. On investigation ,Hemoglobin was found to be 6gm/dl and blood group was B positive by tube method. Request for oneunit of PRBC was received in our blood bank. Blood grouping was re-confirmed and AHG phase crossmatching was performed with B positive PRBC by gel technique. Cross match result was found to be 4+incompatible. On detailed history, patient conceded history of one normal healthy baby and IUD in nextpregnancy 3 months back and also history of breathlessness on transfusion of only 2-5ml of blood thatwas transfused 3 months back after IUD. Further work up was done by performing coombs test, antibodyscreening and identification. Random cross matches with 12 units of B positive were done and 2 unitswere found to be compatible.Results showed positive indirect coombs test and anti-C antibody.Phenotype of patient was DcE/DcE. Her husband phenotype was DCe/DCe. Based on our observation inthis case, we conclude that RhD positive pregnant women should also be considered for antibodyscreening to identify the antibodies against other minor antigens especially the high risk pregnancies andmultigravida.

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