Beta -Cyclodextrin Complexation: A Review On Novel Technique To Enhance Solubility Of Drugs.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Rashmitha Nagamalla¹  Ankita Singh Rajendra¹  Hyma P.¹ 

[1] Department of Pharmaceutics, GITAM School of Pharmacy, GITAM University, Hyderabad Campus

关键词: Beta cyclodextrin;    Inclusion complexation;    solubility;    permeability.;   

DOI  :  10.33887/rjpbcs/2023.14.1.14

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Medicines with low bioavailability and medicines with poor water solubility will have a restrictedtherapeutic effect. Inclusion complexation enables the complexation of the host and guest molecules tochange the physicochemical properties. Therefore, Beta cyclodextrin inclusion complexes are made inorder to augment it using various physical techniques. Several methods can now be used to validate theanalysis of these inclusion complexes, so we discuss the evaluation procedure. How Beta cyclodextrininclusion complexation will truly affect medication solubility and permeability is a significant topic that wewill be emphasizing in this review. This review's goal will also focus on the usefulness and application ofthese agents in goods that are currently on the market. For the advantage of the reader, various ailmentsare mentioned below with FDA-approved enabled products. Due to their increased product stability andemphasis on this as a versatile skin active ingredient, they are receiving a lot of interest in the cosmetic anddermo fields. This procedure truly addresses a number of problems linked to the drug's poor solubility inwater.

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