Association Of Elevated Levels Of Inflammatory Markers And D-Dimer With Psychosis In COVID-19 Patients And A Brief Review Of Possible Underlying Mechanism Of COVID Psychosis- A Retrospective Study In A Tertiary Care Hospital.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Somsubhra Chatterjee¹  Sankha Chatterjee²  Sajeeb Mondal²  Rajashree Pradhan.³ 

[1] Department of Psychiatry, College of Medicine & Sagore Dutta Hospital;Department of Pathology, Rampurhat Government Medical College & Hospital;Department of Pathology, College of Medicine & Sagore Dutta Hospital

关键词: COVID-19;    Psychosis;    D-Dimer;    IL-6.;   

DOI  :  10.33887/rjpbcs/2022.13.6.11

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

COVID-19 disease is caused by Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV- 2). In most of the cases the patients present with typical symptoms of fever, cough, dyspnea, sore throatetc. The involvement of central nervous system by SARS-CoV-2 resulting in encephalopathy, encephalitisand neuropsychiatric symptoms such as anxiety, depression, panic attack and post traumatic symptomshave been described in the literature. But the clinical presentation of Psychosis as a neuropsychiatricmanifestation in COVID-19 patients has been described in very few literatures. Our aim of the study wasto find out the incidence of Psychosis in COVID-19 patients and its association with elevated levels ofinflammatory markers such as IL-6, CRP etc, and with that of elevated coagulation parameter such asD- dimer values. Severity of Pneumonia (by HRCT thorax), neuropsychiatric presentation of Psychosis andthe various interventions received by the COVID-19 patients with Psychosis were also studied. Out of2752 COVID-19 cases new onset COVID Psychosis was seen only in 36 cases with an incidence of 1.308%.Out of these, 30 cases were aged > 60 years (83.3%) with male predominance (n=25)(69.44%) Psychoticmanifestations such as delusion, hallucinations and mania were seen in 34 (94%), 32(88.8%) and 28(77.7%) cases respectively.

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