Research Journal of Pharmaceutical, Biological and Chemical Sciences | |
Preliminary Pharmacological Prospection Of Bioactive Compounds Obtained By Organic Synthesis Against Multidrug-Resistant Gram-Negative Rods. | |
article | |
Jéssica Santos Schirato Albuquerque1  Lucas Silva da Cruz1  Bianca Teixeira Morais de Oliveira2  Luis Cesar Rodrigues3  Ulrich Vasconcelos3  Rafael de Almeida Travassos.4  | |
[1] Laboratório de Farmacobiotecnologia, Universidade Federal da Paraíba;Laboratório de Microbiologia Ambiental, Universidade Federal da Paraíba;Departamento de Biotecnologia, Centro de Biotecnologia, Universidade Federal da Paraíba;Departamento de Biologia Celular e Molecular, Universidade Federal da Paraíba | |
关键词: Bioactive synthetic compounds; alkaloid derivatives; quinazolidines.; | |
DOI : 10.33887/rjpbcs/2022.13.4.6 | |
学科分类:工程和技术(综合) | |
来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences | |
【 摘 要 】
Resistance of pathogenic Gram-negative bacteria to antibiotics is an emerging problem and posesserious challenges for efficient pharmacological treatment. The resistance mechanisms used by thesebacteria can lead to therapeutic failure. Given this, there is a search for novel compounds to control thegrowth of these microorganisms. This work evaluated four substances obtained by organic synthesis(encoded RETRO-2, RETRO-4, MTHP and licarin A) against seven multidrug-resistant Gram-negative rods.The Minimum Inhibitory Concentration (MIC) was determined. All compounds showed activity against atleast two strains; the best results were obtained with RETRO-2 and RETRO-4, whose MICs ranged between-4 -9 10 and 10 M. Enterobacteriaceae were more sensitive than Non-fermenting Gram-Negative Bacilli.Through the sorbitol test, the probable mechanism of action of RETRO-2 and RETRO-4 was by damage tothe cell wall of these bacteria.
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