Preliminary Pharmacological Prospection Of Bioactive Compounds Obtained By Organic Synthesis Against Multidrug-Resistant Gram-Negative Rods.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Jéssica Santos Schirato Albuquerque¹  Lucas Silva da Cruz¹  Bianca Teixeira Morais de Oliveira²  Luis Cesar Rodrigues³  Ulrich Vasconcelos³  Rafael de Almeida Travassos.⁴ 

[1] Laboratório de Farmacobiotecnologia, Universidade Federal da Paraíba;Laboratório de Microbiologia Ambiental, Universidade Federal da Paraíba;Departamento de Biotecnologia, Centro de Biotecnologia, Universidade Federal da Paraíba;Departamento de Biologia Celular e Molecular, Universidade Federal da Paraíba

关键词: Bioactive synthetic compounds;    alkaloid derivatives;    quinazolidines.;   

DOI  :  10.33887/rjpbcs/2022.13.4.6

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Resistance of pathogenic Gram-negative bacteria to antibiotics is an emerging problem and posesserious challenges for efficient pharmacological treatment. The resistance mechanisms used by thesebacteria can lead to therapeutic failure. Given this, there is a search for novel compounds to control thegrowth of these microorganisms. This work evaluated four substances obtained by organic synthesis(encoded RETRO-2, RETRO-4, MTHP and licarin A) against seven multidrug-resistant Gram-negative rods.The Minimum Inhibitory Concentration (MIC) was determined. All compounds showed activity against atleast two strains; the best results were obtained with RETRO-2 and RETRO-4, whose MICs ranged between-4 -9 10 and 10 M. Enterobacteriaceae were more sensitive than Non-fermenting Gram-Negative Bacilli.Through the sorbitol test, the probable mechanism of action of RETRO-2 and RETRO-4 was by damage tothe cell wall of these bacteria.

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