DNA binding activity of new Nickel (II) mixed ligands complexes containing 1, 10-Phenanthroline or 2, 2'-Bipyridine based on Sulfanilic acid.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Adyan A. Yaseen¹  Mouayed A. Hussein.¹ 

[1] Department of Chemistry, College of Science, University of Basrah

关键词: Semicarbazone;    Groove DNA binding;    UV titration;    Binding constant;    Viscosity;   

DOI  :  10.33887/rjpbcs/2022.13.2.17

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Two new nickel complexes with mixed ligands of 1, 10-phenanthroline (1) or 2, 2′-bipyridine (2)based on sulfanilic acid in presence of 5-chloro salicylaldehyde were synthesized. The identity of the13 complexes was determined by CHNS analysis, FTIR, HNMR and CNMR techniques. According to thecharacterization techniques, the structural geometries were suggested as distorted octahedral. Theefficiency of complexes against cancer tumors was investigated by spectroscopic and physical methodsvia in vitro binding with DNA. The results revealed a strong intercalation binding between the complexesand DNA. The extent of binding constant (Kb) was determined and the complex 2 was recorded the higher7 -1 7 -1 value of binding strength (6.4559 x 10 M ) than 1 (6.1238 x 10 M ).

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