Role Of Uromodulin As A Predictor Of Decline In Renal Function.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Praba R¹  Anandhi S²  Mary Arul Priya A.¹ 

[1] Govt. Medical College;Govt. Mohan Kumaramangalam Medical College

关键词: CKD;    eGFR;    Renal function;    Uromodulin.;   

DOI  :  10.33887/rjpbcs/2022.13.1.35

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Uromodulin is a 95 KD protein, released from the basolateral region of tubular cells from where itreaches the interstitial space of the kidneys and detectable levels are usually present in blood. Since it issecreted & synthesised by tubular epithelial cells, its level is decreased in kidney dysfunction. This studyaims to find out the role of uromodulin as a biomarker and its correlation with serum creatinine and eGFRin chronic kidney disease patients. A total of50 controls & 50 cases of CKD patients from stage 1-5 werechosen. Serum uromodulin was measured by ELISA. Sugar, urea, creatinine and lipid profile were measuredusing standard kits. Graph pad prism 8.2.1 used for statistical analysis. Pearson correlation & unpaired ttests were used. Serum uromodulin level was significantly reduced in patients with CKD (p<0.0001).Uromodulin displayed negative correlation with creatinine and positive correlation with eGFR (p <0.01).Inthis study, we have found that serum uromodulin can be used as an early marker of renal dysfunction andalso that it predicts the progression of disease.

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