A Review Article on Role of Medicinal Plant in Gout.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Anand Maury¹  Piyush Yadav¹  Mohit Vishwakarma.¹ 

[1] Prasad Institute Of Technology, Department Of Pharmacy

关键词: URAT1;    xanthine oxidase;    crystal deposition;    uric acid;    kidney disease;    hypertension;    diabetes;    Plant.;   

DOI  :  10.33887/rjpbcs/2022.13.1.29

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Increased uric acid accumulation and / or reduced excretion in humans is closely related to thepathogenesis of gout and hyperuricemia. High purine diets are strongly affected. Uric acid is present inboth high-grade plants and microorganisms dependent on a wide variety of species.Urate degradationenzymes are found in both plants and microorganisms but the ways in which the plant degrades uric acidhave been found to differ from one another. High-yielding plants produce various metabolites that caninhibit xanthine oxidase and xanthine oxido- reductase, thus preventing the inclusion of hypoxanthine inxanthine and uric acid in purine metabolism. However, microorganisms produce a group of enzymes Uricase, allantoinase, allantoicase and urease, causing a decrease in uric acid in ammonia. In humans,researchers found that several mutations caused pseudo genization (Silencing) the gene for urease inancestral monkeys present as soluble crystalloid peroxisomes. This is in contrast to microorganismswhere Ur urine melts and is present in the cytoplasm or peroxisomes In addition, many regenerative Ursurfaces with higher activity than wild uricase can be successfully created for many bacteria. The currentreview concerns the emergence of uric acid in plants and other organisms especially microorganisms inaddition to processes in which extracts of plants, metabolites and enzymes can reduce uric acid in theblood. Genetics and uric acid code for plants and microorganisms are also revealed.gout is a metabolicdisease associated with high uric acid levels in the blood.The disease is treated with other drugs that aimto reduce serum urate levels. However, the use of various drugs leads to the appearance of other sideeffects, which is why it is important to use alternative therapies based on natural sources. Purposeresearch identify alternative therapies, their side effects, and other herbs used to treat gout in Moroccowith the aim of making them more effective . We communicated with various English publications inPubMed, Web of Science, and Science Direct published between 1991 and 2019 using the followingkeywords “drugs,” “gout,” “Morocco,” “medicinal plants,” “in vitro,” and “In terms of vivo. Classify thedrugs, according to their operating procedures, and cite other species reported in the Moroccanpharmacy as anti-cancer effects.

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