The Significance Of Immunohistochemical Expression of CD44 And Ki67 In Patients With Oral Leukoplakia.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Ivona Žužul¹  Ivana Pavic²  Majda Vucic²  Božidar Pavelic³  Ivana Škrinjar⁴  Ema Vindiš⁵  Ana Andabak Rogulj.⁴ 

[1] Department of Oral Surgery, School of Dental Medicine, University of Zagreb;Department of Pathology, University Hospital Centre Sisters of Mercy;Department of Restorative dentistry and endodontics, School of Dental medicine, University of Zagreb;Department of Oral Medicine, School of Dental Medicine, University of Zagreb;Public medical center in Ormož

关键词: oral leukoplakia;    oral squamous cell cancer;    molecular markers;    Ki67;    CD44.;   

DOI  :  10.33887/rjpbcs/2022.13.1.2

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Oral leukoplakia (OL) is a potentially malignant lesion of the oral mucosa with increased risk ofmalignant transformation compared to healthy mucosa. Today, many clinical, histopathological, andmolecular factors are used as potential predictors of malignant transformation. The aim of the research isto immunohistochemically determine the presence of CD44 and Ki67 in OL and to compare the obtaineddata with the presence of CD44 and Ki67 in the oral squamous cell carcinoma (OSCC) and healthy oralmucosa (HOM).Thirty OL, 30 OSCC and 20 HOM were used for immunohistochemical analysis. Significantdifference between groups in relation to the presence of CD44 and Ki67 in the epithelium were detected.Significant difference between groups in relation to the presence of CD44 in II were detected. Significantdifference of Ki67 presence in II has been detected between OSCC and OL, OSCC and HOM, but not betweenOL and HOM. Positive correlations with CD44 both in the epithelium and in the II of OL were detected.Positive correlation between CD44 in inflammation with CD44 and Ki67 in the epithelium of OL weredetected. Increased immunohistochemical presence of CD44 and Ki67 in OL may be a useful predictor ofearly changes in malignant transformation.

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