Design And Characterisation Of Ibuprofen Transemulgel.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

M Surekha¹  S Rahath Fathima¹  A Ganesh.¹ 

[1] Department of Pharmaceutics, P. Rami Reddy Memorial College of Pharmacy

关键词: Ibuprofen;    Emulgel;    Gelling agents;    Transdermal;    Parameters.;   

DOI  :  10.33887/rjpbcs/2021.12.5.3

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

The goal of present project was to study the possibility of trans dermal application of ibuprofenwith emulgel formulations. Ibuprofen (NSAIDs) is hydrophobic in nature it is insoluble in water. Thislimitation was overcome by preparing in the form of emulgel.Ibuprofen Emulgel formulations weredeveloped by using 3 types gelling agents: carbopol 934, carbopol 940 and NaCMC. Ibuprofen emulgelformulations were assessed for different parameters such as physical appearance and pH values, Swellingindex, Spreadability, Extrudibility, Drug content. In-vitro drug release study. All developed emulgelformulations exhibited suitable physical properties relating to colour, homogeneity and consistency.pHvalues of emulgels were seen in the scope of 5.98 to 6.51. Swelling index of all formulations was seen in thescope of 132% to 296%. Spreadability of all emulgel formulations was seen in the scope of 4.0 to 6.3.Extrudability of all emulgel formulations was seen in the scope of 2.34 to 18.5. Drug content of entireemulgel formulations ranged between 73.2% to 112.6%. In- vitro drug release studies showed 69.04% to99.52% release towards the finish of 6 hours. The eventual objective of this drug delivery framework is toaugment therapeutic activity while limiting the negative reactions of the drug. In such manner emulgel ishelps to transfer the ibuprofen drug through the transdermal drug delivery system.

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