Antioxidants And Their Potential Role In Diabetes.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

SU Mohamed Afreeth¹  M Dheepthi¹  S Suba Dhanisha¹  C Sowmya²  R Kaleeswari.² 

[1] Department of Pharmacy Practice, Arulmigu Kalasalingam College of Pharmacy;Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy

关键词: Antioxidants;    Diabetes;    Free radical;    Oxidative stress;    Vitamin C and E;    Flavonoids.;   

DOI  :  10.33887/rjpbcs/2021.12.4.5

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Diabetes is one of the most common disorders affecting about 450 million people around theworld and is rapidly increasing every year. Uncontrolled diabetes leads to variety ofacute and chroniccomplications whicharethe major burden of healthcare system. Oxidative stress and free radical aregenerally detrimental to people and contribute to many chronic health issues. The formation of oxidativestress depends on the intensity of impact of the stress factor and pathology of individual. It is formed byimbalance between production and accumulation of reactive species in the body. Oxidative stress is thevital component in worsening of diabetic conditionincluding resistance to insulin. Antioxidants arecompounds that counteract oxidation thus helping in management of oxidative stress. A balance betweenreactive oxygen species and antioxidants availability in the body is demanded for well physiologicfunctioning. Naturally available antioxidants are adopted due to enormous availability and their leasttoxic effects in the ministration of diabetes mellitus since antioxidants have improved insulin sensitivity.Flavonoids, flavones, catechins, polyphenols, phytoestrogens are some of the plants and food basedantioxidants that are intended to be consumed regularly in addition to vitamin C and vitamin E to inhibitthe progress of oxidative stress. In this article, the significance of antioxidants in management ofhyperglycemic condition and prevention of further consequences are discussed.

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