Spectroscopic Elucidation And DNA Binding Evaluation Of Molybdenum (VI) With 4-Methyl (Methoxy)Benzaldehyde Semicarbazone.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Dunya A. Jameel¹  Mouayed A. Hussein¹  Mohammed J. Bader.¹ 

[1] Department of Chemistry, College of Science, University of Basrah

关键词: Semicarbazone;    Groove DNA binding;    UV titration;    Binding constant;    Viscosity;   

DOI  :  10.33887/rjpbcs/2021.12.3.17

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

In mole ratio 1:2, six molybdenum (VI) complexes were synthesized by the reaction of MoO2(acac)2with semicarbazone ligands derived from 4-methylbenzaldehyde (1A and 2A), and 4-methoxybenzaldehyde(1B and 2B). The synthesized ligands and complexes were structurally characterized by CHNS elemental1 13 analysis and FTIR, HNMR and CNMR spectroscopic techniques. The DNA binding activity with all thecompounds was investigated using the spectral titration method and the viscosity measurement. The resultsrevealed the external groove binding mode of the ligands 2A, 1B and 2B, and all the complexes with DNAwhile, the ligand 1A showed an intercalation binding with DNA. The calculated binding constants (Kb) wereextracted and the values exhibited a noticed binding strength with DNA.

【 授权许可】

All Rights reserved