Healing Activity of Ilex paraguariensis in an Experimental Cicatrization Model.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Ana Carolina Dorigoni Bini¹  Patricia Pacheco Tyski Suckow¹  Andressa Panegalli Hosni¹  Andressa Leticia Miri²  Maria Elvira Ribeiro Cordeiro¹  Carlos Henrique Blum-Silva³  Flávio Henrique Reginatto³  Larissa Sakis Bernardi¹  Jaine Paula Da Luz¹  Ivo Ilvan Kerppers⁴  Paulo Renato de Oliveira.¹ 

[1] Department of Pharmacy, Universidade Estadual do Centro-Oeste;Universidade Estadual de Londrina;Universidade Federal de Santa Catarina;Laboratory of Neuroanatomy and Neurophysiology, Universidade Estadual do Centro-Oeste

关键词: Ilex;    Wound Healing;    Collagen;    Vascular Endothelial Cell Growth Factor;    Transforming Growth Factor Beta.;   

DOI  :  10.33887/rjpbcs/2021.12.3.8

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

The present study aimed to verify the effects of the use of a gel containing Ilex paraguariensis on thecicatrization process of tissue lesions in an experimental model. The in vivo evaluation was performed using adorsal punch model. The sample consisted of 80 male Rattus Norvegicus rats, of Wistar lineage, divided intoControl Group and Gel Ilex Group for 3, 7, 14, and 21 days of treatment. The macroscopic analysis of woundcontraction revealed that the Ilex provided an epidermal regeneration after 21 days of treatment. Thehistological analysis showed, in the intermediate and final inflammatory phases, better delimitation of theepidermis, and proliferation and organization of collagen. The polarized light analysis showed that the groupstreated with Ilex presented an accelerated process of tissue regeneration and mature collagen proliferation inall analyzed periods. The immunohistochemistry analysis showed increased expression of Transforming GrowthFactor Beta (TGF-β1) and Vascular Endothelial Cell Growth Factor (VEGF-α). The Ilex paraguariensis aqueousextract was effective in healing epidermal wounds in an animal model. It is a promising therapy for woundhealing, and so, future studies evaluating adjusted concentrations of extract are suggested.

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