Association between Vitamin-D with Metabolic Parameters in Polycystic Ovarian Syndrome.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Vijayalaxmi BM¹  Lakshmi Manjeera²  Suchetha Kumari N³  Prasanna Kumar Shetty²  Amrith M Mirajkar¹  Shilpa Shetty⁴  Pravesh Hegde⁴  Prajna Bhandary.⁴ 

[1] Dept.of Physiology, K.S. Hegde Medical Academy, Nitte ,(Deemed to be University);Dept.of Obstetrics and Gynecology K.S.Hegde Medical Academy, Nitte ,(Deemed to be University);Dept.of Biochemistry, K.S. Hegde Medical Academy, Nitte ,(Deemed to be University);Central research laboratory, K.S. Hegde Medical Academy, Nitte ,(Deemed to be University)

关键词: PCOS;    Lipid Profile;    HOMA-IR;   

DOI  :  10.33887/rjpbcs/2020.11.5.16

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder that affects women ofreproductive age leading to metabolic alterations such as hyperandrogenism, obesity, menstrual irregularities,insulin resistance, and polycystic ovaries. In the present study, association between vitamin-D with metabolicparameters in polycystic ovarian syndrome in the Indian population was studied. The study population included125 participants with 65 patients diagnosed for PCOS and 60 normal age matched controls. The participants inthe study were included after their informed and written consent. The glucose, insulin, total cholesterol, high- density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides and vitamin D levels wereestimated. IR was estimated using the homeostatic model assessment-IR (HOMA-IR). The FBS, insulin and HOMA- IR showed significantly high in PCOS patients when compared with the control subjects. High Density Lipoproteinwas significantly less in PCOS patient, Low-Density Lipoprotein was significantly high in PCOS patients, but totalcholesterol, triglyceride and HDL/ LDL ratio did not show any significant variation between case and controls.Polycystic ovary syndrome cause endocrine and metabolic imbalance, causing irregular menstrual cycles,dyslipidemia, and infertility.

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