Ex Vivo evaluation of the mucolytic effect from a natural herbal combination of Echinacea purpurea, Sambucus nigra, Glycyrrhiza glabra, Vitex trifolia, and Zingiber officinale.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Rosalina Wisastra¹  Poppy Firzani Arifin.¹ 

[1] OHO Centre of Excellence in Herbal Research ,(SCEHR), SOHO Global Health

关键词: Mucolytic;    E.purpurea;    S.nigra;    G.glabra;    V.trifolia;    Z.officinal;    N-Acetyl cysteine;   

DOI  :  10.33887/rjpbcs/2020.11.1.17

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Mucus plays an important role in respratory system as moisturizing agent and physical of the innateimmune system. The treatment for the overproduction of mucus upon the occurence of allergy or infectionhas gained considerable attention over the years. This study aimed to evaluate the mucolytic activity of naturalherbal combination (NHC) containingEchinacea purpurea herba dry extract, Sambucus nigra (elderberry)fructus extract, Glycyrrhiza glabra (liquorice) radix extract, Vitex trifolia (Indian black pepper) folium extract,Zingiber officinale (ginger) rhizoma extract by ex vivo. The mucolytic activity of this NHC with various doseconcentration 0.25%, 0.5%, 1.0% and 2.0%, was examined by measuring the viscosity of mixture ofcowintestinal mucus and phosphate buffer pH 7 using Viscometer Brookfield LVDV II. N-acetylcysteine (NAC) 0.1%w/v was usedas the standard mucolytic drug. Viscosity values were analyzed statistically usingANOVAsinglefactor to determine differences between treatment groups.Our finding shows that all NHC group has amucolytic effect and the mucolytic effect was identified as dose-dependent . The mucolytic effectfrom 0.5%of NHC is statistically equal to the mucolytic effect from 0.1% NAC. This result could offer a potent plausibeapproach for new mucolytic medication. However, further exploration regarding the other efficacy inmucoactive and its possible mechanism of action are prompt to be done in the future.

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