Spectroscopic And Thermal Investigations Of Olanzapine Drug Charge-Transfer Complexes With Various Acceptors.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Akmal S. Gaballa¹  Sabry A. El-korashy²  Mahmoud M. Ali²  Said M. Teleb.³ 

[1] Faculty of Specific Education, Zagazig University;Chemistry Department, Faculty of Science, Suez Canal University;Chemistry Department, Faculty of Science, Zagazig University

关键词: Charge transfer;    Olanzapine;    I2;    HPA;    H2CA;    HDNS;    TCNQ;    UV-visible;    IR;    H NMR;    TGA;    DTG Spectrometry;   

DOI  :  10.33887/rjpbcs/2019.10.5.14

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Interactions of Olanzapine drug (OLP) as electron donor with various electron acceptors as iodine (I2),picric acid (HPA), chloranilic acid (H2CA), 2,3-dinitrosalsylic acid (HDNS) and 7,7´,8,8´Tetracyanoquinodimethane (TCNQ) were studied in the liquid and solid states. The stoichiometries of allcomplexes were found to be 1:1 molar ratio between olanzapine and acceptors (I , HPA, H CA, HDNS and2 2 TCNQ). The formed CT-complexes were characterized using UV-Visible spectra, photometric titration 1 measurements, IR and H NMR Spectroscopies as well as Thermal analyses. The characteristic physicalconstants (I ), (f), (K ), (), (G), (E ) of the formed CT-complexes are found to be strongly depend on theD CT CT kind and structure of the electron acceptors.

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