The Effect Of Wrightia tinctoria Leaves On CCl4 Induced Hepatotoxicity.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Naiyna Mohamed¹  As Yousuf Ali²  R Parthiban.² 

[1] Department Of Pharmacology, Tiruvarur Medical College;Department Of Pharmacology, K.A.P.V Medical College

关键词: Wrightia tinctoria;    Hepatoprotection;    CCl 4 hepatotoxiciy;    Wistar albino rats.;   

DOI  :  10.33887/rjpbcs/2019.10.4.3

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

The present study has been designed to get better understanding about the actions ofaqueous,alcohol extract and crude powder of Wrightia tinctoria leaves on hepatoprotective effect on wistar albino rats.In this study the efficacy of aqueous, alcohol extracts and crude powder of Wrightia tinctoria leaves for itshepatoprotective effect against CCl induced liver damage was evaluated in Wistar albino rats. The treatment4 schedule and groups are as follows.Group –I control group 1 ml-distilled water (vehicle) was administered for 21 daysGroup –II was exposed to aqueous extract (200 mg/kg ) in 1ml of vehicle for 21 daysGroup–III was exposed to crude leaf powder (500mg/kg) in 1ml of vehicle for 21 daysGroup–IV was exposed alcohol extract (200 mg /kg) in 1 ml of vehicle for 21 days.th At the end of the experimental period on 25 day, blood was collected from retro – orbital venous plexus andanimals were sacrificed autopsied gross pathology examination of all organs and histopathology of liver alsomade, the blood samples were subjected biochemical and hematological investigations. The structuralalterations observed in the histopathological examination of the liver tissue in animals treated with thealcoholic leaf extract after CCl administration was strikingly lesser when compare to hepatic tissue damage of4animals exposed to CCl alone. This observation correlates well with the biochemical changes suggestive of4lesser CCl4 induced hepatic damage in animals treated with the leaf extracts. The extract of the leaves ofWrightia tinctoria have been found to protect experimentally induced liver damage.

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