Research Journal of Pharmaceutical, Biological and Chemical Sciences | |
Solid Dispersion-A Versatile Technique To Enhance Solubility-A Review. | |
article | |
Madhurilatha Thadanki1  Maddi Ramaiah.2  | |
[1] nstitute of Medical Sciences, Department of pharmaceutics;college of pharmacy, Department of pharmacognosy | |
关键词: Solubility; bioavailability; solid dispersion; absorption; poorly water soluble.; | |
DOI : 10.33887/rjpbcs/2019.10.3.42 | |
学科分类:工程和技术(综合) | |
来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences | |
【 摘 要 】
Since decades, it has become a challenging task to the scientist to enhance the solubility of poorlywater-soluble drugs to improve their bioavailability which are given in oral route, by enhancing the dissolutionrate which could be the rate-limiting step in the process of absorption of drug from a solid dosage form ofinsoluble or poorly water-soluble drugs. Based on research, the number of new drug entities which are poorlywater-soluble in nature has adequately increased. Currently, 88-90% of new drug candidates which are highlypotent are poorly water-soluble. The review article focuses on one of simple, novel technique i.e. solid dispersionto enhance the solubility of poorly water-soluble drugs. The review mainly portrays advantages, disadvantages,various techniques available and applications.
【 授权许可】
All Rights reserved
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202307050005230ZK.pdf | 425KB | download |