Urine Strips Test And High Sensitive C - Reactive Protein In Diagnosis Of Spontaneous Bacterial Peritonitis In Egyptian Cirrhotic Patients With Ascites.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Elham Ahmed¹  Magdy fouad²  Ali Hussien Aldahrouty²  Wafaa A Abdelghany²  Alshymaa Ahmed Hassanin²  Waleed Mahmoud Abdelhamid³  Hend M Moness.⁴ 

[1] Internal Medicine, Minia University;Tropical Medicine & Gastroenterology, Minia University;Hematology Clinical pathology department, Minia University;Clinical chemistry Clinical pathology department, Minia University

关键词: SBP;    LERS;    Ascites;    Cirrhosis and hs-CRP.;   

DOI  :  10.33887/rjpbcs/2019.10.3.41

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Ascetic fluid polymorphonuclear leukocyte count (PMNL) 250/mm3 is diagnostic for spontaneousbacterial peritonitis (SBP) but rapid and simple screening test is needed. The aim of our study is to compareleukocyte esterase reagent strips (LERS) and high sensitive c reactive protein (hs – CRP) as two rapid methodsfor diagnosis of SBP in Egyptian cirrhotic patients with ascites. Ascetic fluids of 100 patients with liver cirrhosis,ascites and clinical suspicion of SBP were tested by LERS, hs - CRP and PMNL counts. Patients were divided into2 groups. Group 1: patients with PMNL count≥ 250 cells/ mm3 and group 2: patients PMNL count < 250 cells/mm3. By LERS group 1 were all positive while in group 2 (5) patients were positive and 53 were negative. Thecut-off point of LERS was > grade 2.Sensitivity, specificity, positive predictive value (PPV) and negativepredictive value (NPV) of LERS were 100%, 91.38%, 89.4% and 100% with accuracy 95% area under the curvewas 0.915-0.994.The sensitivity, specificity, PPV and NPV of hs-CRP for SBP diagnosis was 83.33%, 74.14%,70% and 86% respectively with accuracy 0.78% and area under the curve was 0.814. LERS is rapid and bed sidediagnosis for SBP and has higher accuracy than hs-CRP.

【 授权许可】

All Rights reserved