Association Between Soluble Urokinase Plasminogen Activator Receptor And Interleukin 6 In The Diagnosis Of Coronary Artery Disease Patients.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Nahla E El–Ashmawy¹  Eman G Khedr¹  Awad M El Abd²  Amir O Hamouda.³ 

[1] Department of Biochemistry, Faculty of Pharmacy, Tanta University;Department of Biochemistry, Faculty of Medicine, Banha University;Department of Biochemistry, Faculty of Pharmacy, Horus University

关键词: Coronary artery diseases;    biomarkers;    suPAR;    IL-6;    diagnosis;    lipid profile;   

DOI  :  10.33887/rjpbcs/2019.10.3.35

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Coronary artery diseases CAD considered one of a major cause of morbidity and mortality worldwide.suPAR plays a crucial role in the complex pathophysiology of the CAD . IL-6 is a pro-inflammatory cytokine whichis generated in CAD.Therefore, we investigate the diagnostic role and differential value of suPAR and IL-6 in STmyocardial infarction elevation and stable angina.The serum levels of suPAR and IL-6 were measured in 30patients with myocardial infarction, 30 patients with stable angina and 30 healthy volunteers which aredifferentiated by (ECG) at baseline .We also examined the cardiac biomarkers troponin I and CK-MB byimmunoassay and spectrophotometric methods, respectively and Lipid profile .We observed that suPAR and IL- 6 level was significantly different between the myocardial infarction group and the control group (p<0.001) andbetween the stable angina group and the control group (p<0.001).. Furthermore, this result showed a correlationwith the traditional cardiac biomarkers troponin I (+ve r = .725) and CK-MB (+ve r = .421) in myocardial grouppatient. We concluded that suPAR and IL-6 are stable biomarkers and have a positive correlation with cardiacbiomarkers in ST-segment elevation MI patients and patients with stable angina that may aid in the diagnosis ofCAD.

【 授权许可】

All Rights reserved