期刊论文详细信息
Research Journal of Pharmaceutical, Biological and Chemical Sciences
Microwave Assisted Synthesis, Characterization and Biological Study of Some Heterocyclic Derived from Chalcone compounds.
article
Suha K. Al-Mosawi1  Hanan A. Al-Hazam2  Abbas F. Abbas.2 
[1] Department of pharmaceutical chemistry, College of Pharmacy, University of Basrah;Department of Chemistry, College of Science, University of Basrah
关键词: microwave;    chalcone;    antimicrobial;    antifungal.;   
DOI  :  10.33887/rjpbcs/2019.10.3.15
学科分类:工程和技术(综合)
来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences
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【 摘 要 】

A number of heterocyclic compounds were prepared by condensing of chalcones in ethanollic NaOHsolutions. These Heterocyclic were immediately reacted with phenyl hydrazine, hydrazine hydrate,hydroxylamine hydrochloride and thiourea to obtain the corresponding phenyl pyrazole (A1-A10)), pyrazoleacetate (B1-B10), oxazole (C1-C10) and thiopyrimidine (D1-D10) compounds. The synthesized heterocycles werecharacterized on the basis of their chemical properties and spectroscopic data (IR, NMR and MS). Thesecompounds were tested for antimicrobial and fungal activity against a variety of test organisms: Escherichia coli,Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus cereus, aspergillus niger andCandida albicans.

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