期刊论文详细信息
RGUHS Journal of Pharmaceutical Sciences
Evaluation of Cardio Protective Activity of Musa Acuminata in Ischemia-Reperfusion Induced Myocardial Infarction in Rats
article
Uday Raj Sharma1  Ramesh Raju1  Surendra Vada1  Nageena Taj1  Binai Kochunni Sankar1  Abhishek Raj Joshi1  Manjunath Panduranga Mudagal1 
[1] Acharya & BM Reddy College of Pharmacy
关键词: Musa acuminata L;    cardioprotective;    ischemia-reperfusion;    myocardial infarction;    cardiac markers.;   
DOI  :  10.5530/rjps.2018.4.3
学科分类:药学、药理学、毒理学(综合)
来源: Rajiv Gandhi University of Health Sciences
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【 摘 要 】

Heart diseases are the major causes for most of the mortalities in developed and developing countries. Reperfusion damage, once in a while called ischemia-reperfusion damage (IRI) or re-oxygenation damage, is the tissue harm caused when blood supply comes back to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia), so the cardioprotective of the extract of Musa acuminata L. extract in ischemia–reperfusion-induced myocardial infarction in rats are evaluated by measuring the infarct size of the heart and evaluating the serum cardiac markers like Aspartate Aminotransferase (AST/GOT), Alanine Aminotransferase (ALT/GPT), creatinine kinase (CK) and lactate dehydrogenase (LDH). The in vivo cardiac parameters are also taken care because the increase in the anti-oxidant in the body indicates the reduction of the oxidative cell damage. The ethanolic extract of Musa acuminata L. peel showed a significant cardioprotective effect against ischemia reperfusioninduced myocardial infarction in rats. Heart diseases are the major causes for most of the mortalities in developed and developing countries. Reperfusion damage, once in a while called ischemia-reperfusion damage (IRI) or re-oxygenation damage, is the tissue harm caused when blood supply comes back to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia), so the cardioprotective of the extract of Musa acuminata L. extract in ischemia–reperfusion-induced myocardial infarction in rats are evaluated by measuring the infarct size of the heart and evaluating the serum cardiac markers like Aspartate Aminotransferase (AST/GOT), Alanine Aminotransferase (ALT/GPT), creatinine kinase (CK) and lactate dehydrogenase (LDH). The in vivo cardiac parameters are also taken care because the increase in the anti-oxidant in the body indicates the reduction of the oxidative cell damage. The ethanolic extract of Musa acuminata L. peel showed a significant cardioprotective effect against ischemia reperfusioninduced myocardial infarction in rats.

【 授权许可】

CC BY   

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