Evaluation of Cardio Protective Activity of Musa Acuminata in Ischemia-Reperfusion Induced Myocardial Infarction in Rats

RGUHS Journal of Pharmaceutical Sciences

article

Uday Raj Sharma¹  Ramesh Raju¹  Surendra Vada¹  Nageena Taj¹  Binai Kochunni Sankar¹  Abhishek Raj Joshi¹  Manjunath Panduranga Mudagal¹ 

[1] Acharya & BM Reddy College of Pharmacy

关键词: Musa acuminata L;    cardioprotective;    ischemia-reperfusion;    myocardial infarction;    cardiac markers.;   

DOI  :  10.5530/rjps.2018.4.3

学科分类：药学、药理学、毒理学（综合）

来源: Rajiv Gandhi University of Health Sciences

【 摘 要 】

Heart diseases are the major causes for most of the mortalities in developed and developing countries. Reperfusion damage, once in a while called ischemia-reperfusion damage (IRI) or re-oxygenation damage, is the tissue harm caused when blood supply comes back to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia), so the cardioprotective of the extract of Musa acuminata L. extract in ischemia–reperfusion-induced myocardial infarction in rats are evaluated by measuring the infarct size of the heart and evaluating the serum cardiac markers like Aspartate Aminotransferase (AST/GOT), Alanine Aminotransferase (ALT/GPT), creatinine kinase (CK) and lactate dehydrogenase (LDH). The in vivo cardiac parameters are also taken care because the increase in the anti-oxidant in the body indicates the reduction of the oxidative cell damage. The ethanolic extract of Musa acuminata L. peel showed a significant cardioprotective effect against ischemia reperfusioninduced myocardial infarction in rats. Heart diseases are the major causes for most of the mortalities in developed and developing countries. Reperfusion damage, once in a while called ischemia-reperfusion damage (IRI) or re-oxygenation damage, is the tissue harm caused when blood supply comes back to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia), so the cardioprotective of the extract of Musa acuminata L. extract in ischemia–reperfusion-induced myocardial infarction in rats are evaluated by measuring the infarct size of the heart and evaluating the serum cardiac markers like Aspartate Aminotransferase (AST/GOT), Alanine Aminotransferase (ALT/GPT), creatinine kinase (CK) and lactate dehydrogenase (LDH). The in vivo cardiac parameters are also taken care because the increase in the anti-oxidant in the body indicates the reduction of the oxidative cell damage. The ethanolic extract of Musa acuminata L. peel showed a significant cardioprotective effect against ischemia reperfusioninduced myocardial infarction in rats.

【 授权许可】

CC BY