Solid Lipid Nanoparticles Containing Asiaticoside: Development of Topical Delivery Formulation

RGUHS Journal of Pharmaceutical Sciences

article

Satish Chowdahalli Shiva Kumar¹ 

[1]Department of Pharmaceutics, PES College of Pharmacy

DOI  :  10.5530/rjps.2018.2.1

学科分类：药学、药理学、毒理学（综合）

来源: Rajiv Gandhi University of Health Sciences

【 摘 要 】

The present study on Solid Lipid Nanoparticles containing Asiaticoside aims to study the use of solid lipid nanoparticle-enriched hydrogel for the wound healing application of Asiaticoside. Solid lipid nanoparticles (SLNs) were prepared using glycerol tristearate and poloxamer by solvent evaporation method. The particle size, polydispersity index (PDI), zeta potential (ZP), encapsulation efficiency (EE), drug release from nanoparticles and hydrogels, and SEM studies were performed. The prepared SLNs were incorporated in Carboxymethyl chitosan-oxidized alginate hydrogel to form SLN-hydrogel carrier. The hydrogel was evaluated for texture analysis, water vapor transmission, rate of evaporation of water, drug release studies from SLNs and SLN-hydrogel. The best formulation of Asiaticoside based SLNs had high EE (72% ± 6%) and Zeta potential value of -36.8 mV indicating good stability. Formulation N2 showed polydispersivity index less than 1 and the particle size 155 nm to 340 nm. The prepared asiaticoside SLN-hydrogel had water vapour transmission rate of 2294.9±188.9 g/m2 per day which would provide a sufficient level of moisture without risking wound dehydration. The asiaticoside SLN-hydrogel showed sustained release of asiaticoside for 8 h. The present study on Solid Lipid Nanoparticles containing Asiaticoside aims to study the use of solid lipid nanoparticle-enriched hydrogel for the wound healing application of Asiaticoside. Solid lipid nanoparticles (SLNs) were prepared using glycerol tristearate and poloxamer by solvent evaporation method. The particle size, polydispersity index (PDI), zeta potential (ZP), encapsulation efficiency (EE), drug release from nanoparticles and hydrogels, and SEM studies were performed. The prepared SLNs were incorporated in Carboxymethyl chitosan-oxidized alginate hydrogel to form SLN-hydrogel carrier. The hydrogel was evaluated for texture analysis, water vapor transmission, rate of evaporation of water, drug release studies from SLNs and SLN-hydrogel. The best formulation of Asiaticoside based SLNs had high EE (72% ± 6%) and Zeta potential value of -36.8 mV indicating good stability. Formulation N2 showed polydispersivity index less than 1 and the particle size 155 nm to 340 nm. The prepared asiaticoside SLN-hydrogel had water vapour transmission rate of 2294.9±188.9 g/m2 per day which would provide a sufficient level of moisture without risking wound dehydration. The asiaticoside SLN-hydrogel showed sustained release of asiaticoside for 8 h.

【 授权许可】

CC BY